Storage: Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. 

英文别名：Aggrecan; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1; Aggrecan core protein 2; AGC1; CSPG1; MSK16; PGCA_HUMAN.

性状：Lyophilized

纯化方法：HPLC

研究领域：Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Aggrecan Stem Cells > Mesenchymal Stem Cells > Chondrogenesis

活性：Not tested

Background: Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.