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肿瘤坏死因子受体超家族成员14抗体
  • 产品货号：
    BN40818R
  • 中文名称：
    肿瘤坏死因子受体超家族成员14抗体
  • 英文名称：
    Rabbit anti-TNFRSF14 Polyclonal antibody

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  • BN40818R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Dog,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40818R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Dog,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称TNFRSF14
中文名称肿瘤坏死因子受体超家族成员14抗体
别    名HVEM; Tumor necrosis factor receptor superfamily member 14; HVEML; ATAR; CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator A; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; Tumor necrosis factor receptor like gene2; TNR14_HUMAN.   
研究领域肿瘤  细胞生物  免疫学  神经生物学  信号转导  细胞凋亡  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Dog, Horse, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TNFRSF14:51-150/283 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

Function:
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Subunit:
Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses.

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Widely expressed, with the highest expression in lung, spleen and thymus.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 3 TNFR-Cys repeats.

SWISS:
Q92956

Gene ID:
8764

Database links:

Entrez Gene: 8764 Human

Entrez Gene: 230979 Mouse

Omim: 602746 Human

SwissProt: Q92956 Human

Unigene: 512898 Human

Unigene: 215147 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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