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BN40926R-100ul
100ul
¥2470.00
交叉反应：Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
| 英文名称 | Phospho-TH (Ser31) |
| 中文名称 | 磷酸化酪氨酸羟化酶抗体 |
| 别 名 | Tyrosine Hydroxylase (Phospho-Ser31); Dystonia 14; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_RAT; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 内分泌病 细胞类型标志物 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from rat TH around the phosphorylation site of Ser31:VT(p-S)PR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease. Function: Plays an important role in the physiology of adrenergic neurons. Subunit: Homotetramer. Subcellular Location: Mainly expressed in the brain and adrenal glands. Post-translational modifications: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. SWISS: P04177 Gene ID: 25085 Database links: Entrez Gene: 7054 Human Entrez Gene: 21823 Mouse Omim: 191290 Human SwissProt: P07101 Human SwissProt: P24529 Mouse Unigene: 435609 Human Unigene: 1292 Mouse Unigene: 11082 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经细胞标志物 酪氨酸羟化酶（TH）是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶，它以四氢生物喋呤啶(BH4)为辅酶，催化酪氨酸的羟化而生成多巴(DOPA)。 已知在患帕金森病(Parkinson disease,PD)时，脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说，若将TH基因植入脑内，便可以提高脑内DA水平而达到基因治疗目的。 |
