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错配修复蛋白3抗体
  • 产品货号：
    BN41027R
  • 中文名称：
    错配修复蛋白3抗体
  • 英文名称：
    Rabbit anti-MSH3 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41027R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F

  • BN41027R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F

英文名称MSH3
中文名称错配修复蛋白3抗体
别    名Divergent upstream protein; DNA mismatch repair protein; DNA mismatch repair protein Msh 3; DNA mismatch repair protein Msh3; DUC 1; DUC1; DUG; DUP; hMSH3; MGC163306; MGC163308; Mismatch repair protein 1; MRP 1; MRP1; MSH 3; MSH3; MSH3_HUMAN; MutS homolog 3 (E. coli); MutS homolog 3.  
研究领域细胞生物  免疫学  染色质和核信号  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量127kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MSH3:521-620/1137 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Subunit:
Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].

Similarity:
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

SWISS:
P20585

Gene ID:
4437

Database links:

Entrez Gene: 4437 Human

Entrez Gene: 17686 Mouse

Omim: 600887 Human

SwissProt: P20585 Human

SwissProt: P13705 Mouse

Unigene: 280987 Human

Unigene: 343101 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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