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BN41602R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41602R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41602R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
| 英文名称 | CD38 |
| 中文名称 | CD38抗体 |
| 别 名 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN; CD38_MOUSE; I-19; NIM-R5 antigen. |
| 研究领域 | 肿瘤 免疫学 干细胞 糖尿病 细胞表面分子 自然杀伤细胞 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CD38:101-200/304 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Similarity: Belongs to the ADP-ribosyl cyclase family. SWISS: P56528 Gene ID: 12494 Database links: Entrez Gene: 952 Human Entrez Gene: 12494 Mouse Omim: 107270 Human SwissProt: P28907 Human SwissProt: P56528 Mouse Unigene: 479214 Human Unigene: 249873 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD38分子是单链Ⅱ型跨膜糖蛋白，存在于很多免疫细胞表面上,CD38与无脊椎动物卵的授精、HIV感染、某些癌症以及糖尿病等有关，CD38具有许多复杂而又独特的生物学特性及功能，有调控细胞钙释放的机制。主要表达于胸腺细胞、前T和前B细胞、活化的T和B细胞、单核细胞、NK细胞、浆细胞等，可用于急性白血病的分型和活化的T细胞在自身免疫和免疫缺陷中的作用等方面的研究，也可作为生发中心B细胞的一种选择性标记。 |
